The constructs, termed ‘medusoids’, were designed with computer simulations and experiments to match key determinants of jellyfish propulsion and feeding. Enter the era of synthetic physiology! Why not build a jellyfish from neonatal rat heart cells and some plastic? This is exactly what was accomplished in this study. jellyfish. This engineered jellyfish displays behavior such as propulsion and swimming when A tissue engineered jellyfish with biomimetic propulsion .
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A tissue-engineered jellyfish with biomimetic propulsion — UC Davis
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Reverse engineering of biological form and function requires hierarchical design over several orders of space and time. Recent advances in the mechanistic understanding of biosynthetic compound materials, computer-aided design approaches in molecular synthetic biology 4,5 and traditional soft robotics, and increasing aptitude in generating structural and chemical micro environments that promote cellular self-organization have enhanced the ability to recapitulate such hierarchical architecture in engineered biological systems.
Here we combined these capabilities in a systematic design strategy to reverse engineer a muscular pump. We report the construction of a freely swimming jellyfish from chemically dissociated rat tissue and silicone polymer as a proof of concept.
The constructs, termed ‘medusoids’, were designed with computer simulations and experiments to match key determinants of jellyfish propulsion and feeding performance by quantitatively mimicking structural design, stroke kinematics and animal-fluid interactions.
The combination of the engineering design algorithm with quantitative benchmarks of physiological performance suggests that our strategy is broadly applicable to reverse engineering of muscular organs or simple life forms that pump to survive. Funding information This work was supported by: This entry form currently does not support special characters.
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You have a close personal relationship e. You are a close professional associate of any of the jellyrish e. Tissue-engijeered work at the same institute as any of the authors.
Medusoid, A Tissue-Engineered Jellyfish with the Ability to Swim
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